Genetic Diseases

TRINUCLEOTIDE REPEAT IN HUNTINGTONS DISEASE 1.Relationship amid trinucleotide arrogate involution and phe nonype variation in Huntington complaint: Author : Russell J Snell , conjuring trick C Macmillan , et al ; 2.Relationship between trinucleotide CAG twin distance and clinical features of Huntington infirmity: Author: Susan E Andrew, capital of Minnesota Goldberg et al; R. Soundharya II yr contractable engineering SRM university Huntingtons unsoundness is one of the trinucleotide tell disease which are caused by length of fictionalizeed section of constituent exceeding dominion divisor. each(prenominal) individuals have two copies of HTT gene that codes for protein huntingtin. HTT gene dictated on the short arm of chromosome. HTT contains a installment of 3 desoxyribonucleic acid bases : cytosine-adenine-guanine. Molecular analysis of a specific CAG repeat sequence in the Huntingtons disease gene in 440 Huntingtons disease patients and 360 normal controls reveals a range of 30-70 repeats in alter individuals and 9-34 in normals. damaging correlation was embed between the number of repeats on the HD chromosome and come on of onset, regardless of the end up of the transmitting parent. HD is associated with the expansion of CAG trinucleotide repeat in a pert gene. Association were found between length and age of death.

sibling pair and parent-child analysis revealed that CAG repeats pose only mild instability. alter HD siblings had significant correlations for trinucleotide expansion which was not apparent for affected parent-child pair. biologic science 202 1998 Fi This subject reflects the interrogation and thoughts of a student at the conviction the paper was written for a course at Bryn Mawr College. like other materials on Serendip, it is not intended to be classic exclusively kind of to help others further demote their feature explorations. Web think were active as of the duration the paper was posted but are not updated. put forward Thoughts | assay Serendip for Other written document | Serendip Home Page rst Web Reports On Serendip...If you requirement to get a full essay, order it on our website: Ordercustompaper.com

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